American Splendor

Ebon Moss-Bachrach

MTV Director

Paul Giamatti

Harvey Pekar

Madylin Sweeten

Danielle

Daniel Tay

Young Harvey

Danny Hoch

Marty

Larry John Meyers

Throat Doctor

Hope Davis

Joyce Brabner

James Urbaniak

Robert Crumb

Molly Shannon

Stage Actor Joyce

Maggie Moore

Alice Quinn

Earl Billings

Mr. Boats

David Letterman

Self (archive footage)

Judah Friedlander

Toby Radloff

Donal Logue

Stage Actor Harvey

James McCaffrey

Fred

Vivienne Benesch

Lana

Harvey Pekar

Real Harvey

Josh Hutcherson

Robin

Joyce Brabner

Joyce Brabner

Toby Radloff

Toby Radloff

Eytan Mirsky

Guitarist

Joey Krajcar

Batman

Chris Ambrose

Superman

Cameron Carter

Green Lantern

Mary Faktor

Housewife

Kurt Loder

Self (archive footage)

Shari Springer Berman

Interviewer (voice)

Barbara Brown

Nurse

Eli Ganias

Pahls

Sylvia Kauders

Old Jewish Lady

Rebecca Borger

Cashier

Nick Baxter

Mattress Guy #1

Allen Branstein

Mattress Guy #2

Dick Prochaska

WWII Patient

Charles Eduardos

Doctor

Robert Pulcini

Bob the Director

Bianca Santos

Counter Girl

Mike Rad

Rand

Amy K. Harmon

Cheery Waitress

Rob Grader

Stage Manager

Terrence Sullivan

Letterman Regular

Patrick Lafferty

Yuppie

Jesse Perez

Miguel

Jeff Peters

Talk Show Host

Ola Creston

PA #1

Robert J. Williams

Cancer Doctor

Jason Stevens

Letterman Regular (voice)

Todd Cummings

Talk Show Host (voice)