Season 5

Live in the moment and dive deeper into the world of Grey's Anatomy. Follow the doctors as they wrestle with formidable challenges and navigate uncharted territories of life. Experience the on-again, off-again dynamic of Derek and Meredith, and witness Cristina and Owen's budding relationship—Owen, Seattle Grace's newest doctor.

200824 EpisodesDrama

Cast & Crew

Patrick Dempsey

Derek Shepherd

Sara Ramirez

Callie Torres

Sandra Oh

Cristina Yang

James Pickens Jr.

Richard Webber

Katherine Heigl

Izzie Stevens

Eric Dane

Mark Sloan

Chyler Leigh

Lexie Grey

Kevin McKidd

Owen Hunt

Chandra Wilson

Miranda Bailey

Justin Chambers

Alex Karev

Ellen Pompeo

Meredith Grey

T. R. Knight

George O'Malley

Episode Guide

As Meredith and Derek discover that their 'happily ever after' isn't as effortless as they hoped, Cristina develops a crush on a military doctor who arrives with a trauma patient. Meanwhile, the Chief and his staff grapple with the news that Seattle Grace has fallen from its status as a premier teaching hospital.