Igor

Steve Buscemi

Scamper (voice)

John Cusack

Igor (voice)

Jennifer Coolidge

Jaclyn / Heidi (voice)

John Cleese

Dr. Glickenstein (voice)

Christian Slater

Dr. Schadenfreude's Igor (voice)

Frank Welker

Animals' vocal effects (voice) (uncredited)

Jess Harnell

Announcer / Royal Guard #2 (voice)

Suzy Eddie Izzard

Dr. Schadenfreude (voice)

Jay Leno

King Malbert (voice)

Sean Hayes

Brain (voice)

Arsenio Hall

Carl Cristall (voice)

Molly Shannon

Eva (voice)

Robin Walsh

Dr. Holzwurm's Igor (voice)

Paul Vogt

Buzz Offmann (voice)

James Lipton

Himself

Tony Leondis

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Myleene Klass

Dr. Holzwurm (voice)

Matt McKenna

Dr. Herzschlag (voice)

Zoë Bright

Blind Woman / Killiseum Fan #1 (voice)

Sophia Eraklis

Blind Orphan #1 (voice)

A. Cheron Hall

Blind Orphan #2 / Blind Orphan #4 (voice)

Alexander Leondis

Blind Orphan #3 (voice)

Michael Leondis

Blind Orphan #6 (voice)

Nicole Leondis

Blind Orphan #7 (voice)

Juliana Leondis

Blind Orphan #5 (voice)

Robin Tisserand

Blind Orphan #8 (voice)